Diagnostic Potential Of Extant Antischistosoma Genus-specific Monoclonal Antibodies

113 pages ID: BCH0174

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Project Details

DepartmentBio-Chemistry
TypeProject
Pages113
Reference StyleYES
FormatMS Word & PDF
Reference No.BCH0174

Abstract

ABSTRACT The suitability o f five Schistosoma genus-specific monoclonal antibodies (MoAbs) (Sh3/34.10, Sh3/38.2, Sh4/14.3, Sh5/32.30 and Sh5/34.10) in detecting schistosome antigens in infected human and cattle was evaluated. These antibodies were employed in various diagnostic assays to diagnose human and animal schistosomiasis. Extant MoAb secreting hybridoma cells were first propagated in culture to produce the MoAbs. The culture supernatants containing secreted antibodies were analysed by immunodiffusion and the isotypes o f the immunoglobulins shown to be IgM (Sh3/34.10, Sh3/38.2, Sh5/32…

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Pages113
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