Antimalarial And Antioxidant Effects Of Methanol And Flavonoid-rich Extracts Of Adansonia Digitata Stem Bark On Plasmodium Berghei-infected Mice

ABSTRACT Adansonia digitata has popular ethnomedicinal application in the treatment of malaria in sub-Saharan Africa. The present study sought to investigate the antimalarial and antioxidant effects of methanol and flavonoid-rich extracts of the stem bark on Plasmodium berghei-infected mice in vivo. Thirty-five male mice, weighing 18-20 g and randomly allocated into seven groups of five animals each were used. Group 1, which served as the positive control, was pretreated with 1 ml/kg of the vehicle (5% v/v tween 80), mice in groups 2 and 3 were pretreated with 5 mg/kg b.wt of the standard dru…