Synthesis And Evaluation For Biological Activities Of Npyridin-3-yl Substituted [phenylsulphonamido] Acetamide

89 pages ID: CHM0114

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DepartmentChemistry
TypeProject
Pages89
Reference StyleYES
FormatMS Word & PDF
Reference No.CHM0114

Abstract

ABSTRACT In this study, a series of N-pyridin-3-yl substituted [phenylsulphonamido] acetamide has been synthesized. The reaction of phenylsulphonyl chloride with various amino acids in basic medium yielded phenylsulphonamido alkanoic acid which, on chlorination with thionyl chloride, gave acid chloride derivatives of phenylsulphonamido alkanoic acid in situ. The acid chloride derivatives on condensation with 3-aminopyridine gave corresponding acetamide in good to excellent yield. The compounds were characterized by FTIR, 1 H-NMR and 13CNMR and screened for antibacterial, antifugal and antioxi…

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