Synthesis Of N-(heteroaryl Substituted) Benzene Sulphonamides And Their Biological Activities

ABSTRACT The synthesis of N-heteroaryl substituted benzene sulphonamides and evaluation of their biological activities are reported. Synthesis was achieved by the reaction of benzene sulphonyl chloride and substituted amino heterocycle in dry pyridine. The structures of synthesized compounds were assigned by spectroscopic methods. The eight (8) synthesized compounds were evaluated for antibacterial and antifungal activities. The results showed that some of the new compounds exhibited activities comparable to ciprofloxacin and ketoconazole. Acute toxicity (LD50) of the synthesized samples was …