Palladium–catalyzed Sonogashira Synthesis Of Mono And Bisalkynylated Derivatives Of Quinoline-5,8-dione And Their Antimicrobial Activity

141 pages ID: IDC0051

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DepartmentIndustrial Chemistry
TypeProject
Pages141
Reference StyleYES
FormatMS Word & PDF
Reference No.IDC0051

Abstract

ABSTRACT The synthesis of five mono- and five bis-alkynylated derivatives of quinoline-5,8-diones is reported. The intermediate 6,7-dibromoquinoline-5,8-dione was obtained by nitrosation of 8- hydroxyquinoline, followed by reduction and subsequent bromination and oxidation. The coupling reaction of 6,7-dibromoquinoline-5,8-dione via palladium-catalyzed Sonogashira cross-coupling gave the alkynylated products. The chemical structures of the products were confirmed using spectroscopic methods which include UV-visible spectrophotometry, Fourier Transform-Infrared (FT-IR) spectroscopy, 1 H and 13…

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