Antibody Responses To Variant Surface Antigens And Biomarkers Of Endothelial Damage And Repair In The Development Of Cerebral Malaria

ABSTRACT Background: The pathogenesis of cerebral malaria (CM) is still recognized as multifaceted, despite the plausible explanation provided by the high degree of sequestration of parasitized erythrocytes in major organs of the body. Postmortem studies have demonstrated the presence of hemorrhage, deposition of fibrin and clots in blood vessels of the body where sequestration has been observed. These findings support a potential association between sequestration, endothelial damage and repair, in the development of cerebral malaria. Considering the evidence, it is plausible that associated…