Predicting Intestinal Permeation Of Drugs Through Neural Network Analysis Based On Five Molecular Descriptors

ABSTRACT The oral route is generally preferred for drug administration because of its ease and good patient compliance. In the search for new drugs for oral administration a major problem encountered is obtaining drug structures which, as well as being potent in viiro, possess favourable pharmacokinetic profiles which enable them to pass easily through the relevant body membranes, especially the gastrointestinal epithelia to effect their action. However, many of the compounds derived from combinatorial synthesis and high throughput screening have inappropriate properties for oral absorption, s…