Protective Role Of Aqueous Leaf Extract Of Vernonia Amygdalina Del. (asteraceae) And Ocimum Gratissimum Linn (lamiaceae) In Cyclophosphamide Induced Urotoxicity And Myelosuppression

112 pages ID: PHS0036

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DepartmentPharmaceutical Science
TypeProject
Pages112
Reference StyleYES
FormatMS Word & PDF
Reference No.PHS0036

Abstract

ABSTRACT  Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced urotoxicity and myelosupression were evaluated using biochemical and histopathological approaches. Sodium -2-macarptoethane sulfonate (MESNA) was used as a positive control. Forty (40) male Sprague-Dawley outbred albino rats weighing between 130 g – 200 g wer…

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