Evaluation Of The Subacute And Delayed Toxicity Of Artemether-lumefantrine Combination In Rats

136 pages ID: PHS0037

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DepartmentPharmaceutical Science
TypeProject
Pages136
Reference StyleYES
FormatMS Word & PDF
Reference No.PHS0037

Abstract

ABSTRACT  Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the subacute and delayed toxicity of artemether-lumefantrine combination (ALC). In this study, rats in groups I-VI were administered varying concentrations of oral artemether-lumefantrine combination as a single dose for 7 days. The animals in groups I-III w…

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