Evaluation Of The Antiplasmodial Activity Of Methanol Leaf Extract And Fractions Of Landolphai Owariesis P. Beauv (apocynaceae) In Mice

ABSTRACT  Landolphia owariensis P. Beauv (Apocynaceae) is a woody liane commonly used in Africa for the treatment of gonorrhea, worm infestation and malaria. The methanol leaf extract (ME) of L. owariensis was obtained by cold maceration and then fractionated into nhexane (nHF), ethylacetate (EF) and methanol (MF) fractions. The methanol extract and fractions were tested against chloroquine-sensitive Plasmodium berghei berghei in early, established and repository models of infection using Peter’s 4-day suppressive model, Rane’s curative model and Peters prophylactic model respectively. The ant…