Biochemical Remedy For Sickle Cell Disease

35 pages Chapters 4 ID: SLT0165

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DepartmentScience Lab Technology
TypeProject
Pages35
Chapters4
MethodologyDescriptive
Reference StyleYES
FormatMS Word & PDF
Reference No.SLT0165

Abstract

BIOCHEMICAL REMEDY FOR SICKLE CELL DISEASEABSTRACTSickle cell disease is a hereditary condition that result from a single glutamic acid to valine substitution of position 6 of the beta globin polypeptide chain. It is inherited as an autosomal recessive trait. This glutamic aicd being subsituted by valine is characterized by drastic reduction in the solubility of sickle cell haemoglobin (Hbs) when deoxygenated. Under these conditions, the Hbs molecules polymerize to form long crystalline intracellular mass of fibres which are responsible for the deformation of the bioconcave disc shaped erythro…

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