Effects Of Aluminum- Magnesium On The Antiplasmodial Activity Of Chloroquine Phosphate In Mice

91 pages ID: VEM0025

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DepartmentVeterinary Medicine
TypeProject
Pages91
Reference StyleYES
FormatMS Word & PDF
Reference No.VEM0025

Abstract

ABSTRACT Effect of stabilizing chloroquine phosphate in a synthetic Aluminium Magnesium silicate (Nanoparticles) on the antiplasmodial activity of the drug was investigated. Mice infected with Plasmodium berghei were treated with chloroquine phosphate at 7 mg/kg, 5 mg/kg and 3 mg/kg dose levels respectively. Two subgroups at each dose level were treated with chloroquine phosphate alone and with a drug formulation of 20% chloroquine phosphate in the synthetic Aluminium Magnesium Silicate (AMS) as an adjuvant. Percentage Plasmodium berghei parasitaemia (parasite/ml), Red blood cell (Rbc) count,…

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Pages91
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