Effects Of Aqueous Ethanolic Leaf Extracts Of Mucuna Puriens And Chromolaena Odorata On Isolated Uterine Smooth Muscle Of The Albino Rat

107 pages ID: VEM0027

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DepartmentVeterinary Medicine
TypeProject
Pages107
Reference StyleYES
FormatMS Word & PDF
Reference No.VEM0027

Abstract

ABSTRACT The contractile activity of M. pruriens and the relaxatory property of C. odorata was investigated using in vitro methods in the rat. M. pruriens caused a dose-dependent increase in uterine muscle contraction with a maximum peak in amplitude with 0.57 mg/ml of the extract and an EC50 of 2.7 mg/ml. The contraction was unaffected by atropine sulphate (0.042 µmol), but abolished by isoprenaline (0.06-0.23 µmol), salbutamol (0.012-0.4 µmol) and adrenaline (16 nmol).Uterine muscle contractions were enhanced by propranolol (1 µmol) in a dose- dependent manner. Prazosin (0.069-0.14 µmol) an…

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