Effects Of Aqueos Extract Of Bitter Kola (garcinia Kola) On The Pregnancy Outcome And Early Postnatal Development Of The Offspring Of Diabetic Pregnant Rats

ABSTRACT Increased oxidative stress arising from the maternal hyperglycemic-induced disturbances in fetal metabolism has been suggested to play a role in the pathogenesis of disturbed embryogenesis in diabetic pregnancies. Maternal diabetes in pregnancy and the associated hyperglycemia is also believed to expose the fetus to disturbed metabolic conditions in-utero creating a ‘metabolic memory’ that programs the fetus for glucose intolerance, diabetes mellitus and obesity later in life. Bitter kola (Garcinia kola) is a medicinal plant with a wide range of pharmacological effects including ant…