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This study sought to assess the knowledge on the use of Artemether/ therapy in the management of uncomplicated malaria among out patients treated at KlU-TH. A cross sectional study design was employed in this study. Data was collected from August to October 2018 using a questionnaire by simple Random sampling and was entered and analyzed… Continue Reading
The bioavailability of drugs from conventional eye drops is generally low. Many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense… Continue Reading
Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and… Continue Reading
Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with… Continue Reading
ABSTACT The pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated. The analgesic… Continue Reading
Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for… Continue Reading
Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods: The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided… Continue Reading
TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE---------i DECLARATION--------ii CERTIFICATION--------iii DEDICATION--------iv ACKNOWLEDGEMENT-------v TABLE OF CONTENT-------vi LIST OF TABLES--------ix LIST OF FIGURES-------ix ABSTRACT---------x CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW 1.1 TRADITIONAL MEDICINE-------1 1.2 MODERN MEDICINE--------4… Continue Reading
Landolphia owariensis P. Beauv (Apocynaceae) is a woody liane commonly used in Africa for the treatment of gonorrhea, worm infestation and malaria. The methanol leaf extract (ME) of L. owariensis was obtained by cold maceration and then fractionated into nhexane (nHF), ethylacetate (EF) and methanol (MF) fractions. The methanol extract… Continue Reading
Leaf of Vernonia amygdalina has been shown to have hypoglycemic activity. This may be as a result of the presence of secondary metabolites as its constituents. The major secondary metabolites present in the leaf are tannins, carbohydrates, reducing sugars, glycosides, steroids and proteins. This work was designed to identify these… Continue Reading
Introduction:Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and… Continue Reading
Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the… Continue Reading
Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced… Continue Reading
Ceiba pentandra is a tropical tree of order Malvales and the family Malvaceae. The basic objective of this research work is to determine the antimicrobial and phytochemical properties of Ceiba pentandra. Fresh leaves and bark of Ceiba petandra was collected at Akungba Akoko. Ceiba pentandra (leaf and bark) were prepared for extraction… Continue Reading
The purpose of this research work is to determine the microbiological profile of hospital solid waste dump sites, sensitivity to antibiotic and isolation and identification of the organism using API 20 E kit method of analysis. Microbiological profiling was carried out on hospital solid waste collected from State Specialist Hospital in… Continue Reading
Anisopus mannii(Asclepiadaceae) –is a glabrous twining shrub, strong climber with greenish flower in globose, lateral umbelliform cymes it is widely used as an anti-diabetic agent in Northern and southern Nigerian traditional medicine, Studies were conducted to determine the phytochemical constituents of leaf and bark ethyl acetate extracts of… Continue Reading
Piliostigma reticulatum plant found in West Africa. It is an Evergreen shrub with a twisted bole to 9 m high, with a bushy spherical canopy. Bark dark grey to brown, fibrous and corky, slash dark red. Leaves large, thick, leathery, grey-green, 6-12 cm long, Fruit large, long, straight, undulate or twisted and hard, either glabrous or sparsely… Continue Reading
The purpose of this present study of seven Nigerian medicinal plants is to ascertain the medicinal, phytochemical and proximate constituents of the plants. The plants are .Acacia albida Del, Anchomanes difformis Engl, Boscia senegalensis, Bridelia ferruginea Benth, Ficus ingens (Miq.) Miq, Indigofera arrecta Hochst and … Continue Reading
The increasing incidence of resistance to antibiotics among bacteria currently poses serious clinical and public health threat and has propelled efforts for newer alternatives to alleviate the problem. Extensive search and testing for different plants with potentials for antimicrobial properties is presently considered one of the most feasible… Continue Reading
Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female albino rats. In-vivo toxicity test was carried out with modified Lorke’s method. Forty two (42) male and female albino… Continue Reading
The seeds of a tropical fruit Carica papaya have been proven to have anthelminthic activity. The main component in the seeds responsible for this activity is Benzyl isothiocyanate. It is effective against parasites such Ascaris lumbricoides, Strongyloides stercoralis, Taenia saginata and so on. The research focus on formulating an… Continue Reading
Microsphere drug delivery systems are used to protect sensitive drugs from enzymatic degradation in the body, for controlled release and tissue targeting of the drug of interest. Starch and products derived from starch modification, are increasingly gaining acceptance in microsphere drug delivery. They are less expensive, non-toxic,… Continue Reading
In the present study, optimized binary lipid matrices of Tallow fat- Transcutol and Precirol-Transcutol were used to formulate sustained release solid lipid nanoparticles loaded lumefantrine and ciprofloxacin. The homolipid (tallow fat from Bos indicus was extracted and purified following standard methods. Abinitio selection of lipid… Continue Reading
Starch is a naturally occurring polymer found in parts of the plants such as leaves, stems, tubers, and fruits. It is a commonly used excipient in pharmaceutical formulations because of its availability, affordability and inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country especially in the northern part of… Continue Reading
Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered… Continue Reading